20 research outputs found
High-density functional-RNA arrays as a versatile platform for studying RNA-based interactions
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Get PDFWe are just beginning to unravel the myriad of interactions in which non-coding RNAs participate. The intricate RNA interactome is the foundation of many biological processes, including bacterial virulence and human disease, and represents unexploited resources for the development of potential therapeutic interventions. However, identifying specific associations of a given RNA from the multitude of possible binding partners within the cell requires robust high-throughput systems for their rapid screening. Here, we present the first demonstration of functional-RNA arrays as a novel platform technology designed for the study of such interactions using immobilized, active RNAs. We have generated high-density RNA arrays by an innovative method involving surface-capture of in vitro transcribed RNAs. This approach has significant advantages over existing technologies, particularly in its versatility in regards to binding partner character. Indeed, proof-of-principle application of RNA arrays to both RNA-small molecule and RNA-RNA pairings is demonstrated, highlighting their potential as a platform technology for mapping RNA-based networks and for pharmaceutical screening. Furthermore, the simplicity of the method supports greater user-accessibility over currently available technologies. We anticipate that functional-RNA arrays will find broad utility in the expanding field of RNA characterization
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
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- Agarwal D.
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- Ajith Parameswaran
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Get PDFGravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
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- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
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- Agathos Michalis
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- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
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- Altin Paul
- Amato Alex
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- Andrea Prodi Giovanni
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- Andrés-Carcasona Marc
- Anne Bizouard Marie
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- Antier Sarah
- Antonio Font Roda Jose
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- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Get PDFDespite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
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- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
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- Agarwal Deepali
- Agathos Michalis
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- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
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- Tanner D. B.
- Tao Liu
- Tapia San Martín E. N.
- Tapia R. D.
- Tarafder R.
- Taranto C.
- Taruya Atsushi
- Tasson Jay
- Teloi M.
- Tenorio Rodrigo
- Themann H.
- Theodoropoulos A.
- Thirugnanasambandam M. P.
- Thomas M.
- Thomas P.
- Thompson Jonathan
- Thondapu S. R.
- Thorne K. A.
- Thrane E.
- Tissino Jacopo
- Tiwari A.
- tiwari shubhanshu
- Tiwari Srishti
- tiwari vaibhav
- Todd M. R.
- Toivonen Andrew
- Toland Karl
- Tolley Arthur E.
- Tomita K.
- Tomura Tomonobu
- Tong-Yu C.
- Toriyama A.
- Toropov Nikita
- Torres Forne Alejandro
- Torrie C. I.
- Toscani Martina
- Tosta e Melo Iara
- Tournefier Edwige
- TRAPANANTI Angela
- Travasso Flavio
- Traylor G.
- Trenado Juan
- Trevor M.
- Tripathee Aashish
- Troiano L.
- Trovato Agata
- Trozzo L.
- Trudeau R. J.
- Tso R.
- Tsuchida Satoshi
- Tsukada L.
- Tsutsui Takuya
- Turbang Kevin
- Turconi Margherita
- Turski C.
- Ubach Helena
- Ubhi A. S.
- Uchiyama Takashi
- Udall Rhiannon
- Uehara Tomoyuki
- Ueno Koh
- Unnikrishnan C. S.
- Ushiba Takafumi
- Vacatello Michele
- Vahlbruch Henning
- Vaidya Nina
- Vajente Gabriele
- Vajpeyi A.
- Valdes Guillermo
- Valencia J.
- Valentini Michele
- Vallejo-Peña S. A.
- Vallero S.
- Valsan Vinaya
- Valérie Martinez
- van Bakel N.
- van Beuzekom Martin
- van Dael Mathyn
- Van de Walle A.
- van den Brand Johannes
- Van Den Broeck C.
- van der Sluys Marc
- van Dongen Jesse
- Van Haevermaet Hans
- van Heijningen Joris
- van Putten Maurice
- Van Ranst Zeb
- van Remortel Nick
- Vander-Hyde D. C.
- Vandra K.
- Vanosky J.
- Vardaro M.
- Vargas A. F.
- varma vijay
- Vasuth Matyas
- vecchio alberto
- Vedovato G.
- Veitch John
- Veitch Peter
- Venikoudis S.
- Venneberg Jasper
- Verdier Patrice
- Verkindt Didier
- Verma B.
- Verma P.
- Verma Yogesh
- Vermeulen Sander M.
- Veske Doğa
- Vetrano F.
- Veutro A.
- Vibhute Ajay
- Viceré Andrea
- Vidyant S.
- Viets Aaron
- Vijaykumar Aditya
- Vilkha A.
- Villa-Ortega Verónica
- Vincent Erin
- Vinet J. -Y.
- Viret S.
- Virgo Collaboration
- Virtuoso Andrea
- Vitale Salvatore
- Vocca H.
- Voigt Daniel
- von Reis E. R. G.
- von Wrangel J. S. A.
- Vyatchanin Sergey P.
- Wade L. E.
- Wade Madeline
- Wagner Katelyn
- Walet R. C.
- Walker M.
- Wallace G. S.
- Wallace L.
- Wang Haoyu
- Wang J. Z.
- Wang W. H.
- Wang Z.
- Waratkar Gaurav
- Ward R. L.
- Warner J.
- Was Michal
- Washimi Tatsuki
- Washington N. Y.
- Watarai D.
- Wayt K. E.
- Weaver B.
- Weaving C. R.
- Webster S. A.
- Weinert M.
- Weinstein Alan J.
- Weiss R.
- Weizmann Kiendrebeogo R.
- Weller C. M.
- Weller Robert
- Wellmann F.
- Wen L.
- Wette Karl
- Weßels P.
- Whelan John
- White D. D.
- Whiting Bernard F.
- Whittle Chris
- Wildberger J. B.
- Wilk O. S.
- Wilken Dennis
- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williams N. S.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Wolfe N. E.
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright J. L.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Get PDFAmong the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
An in-depth analysis of barriers to corporate sustainability?
- Publication venue
- 'MDPI AG'
- Publication date
- 06/01/2025
- Field of study
No full textEstablishing sustainable and resilient businesses are among the key drivers behind the unprecedented demand for the transition and transformation of sustainable growth models. Driven by a desire to remain competitive amidst economic turmoil and climate change, organisations are embedding sustainable measures into their long-term goals and strategies. This is demonstrated by developing and implementing Net-Zero targets and associated plans. However, the greatest challenge is whether such momentum will be retained and how organisations can maintain the drive. Although this is a positive move towards climate-related actions from organisations and stakeholders, it is taking longer than anticipated to be realised and actualised. This necessitates the urgency in understanding the intricacies of corporate sustainability matrices. The question as to why attaining a positive climatic state has taken almost half a century needs to be explored when compared to scenarios where the implementation of sustainable related measures has taken less time. This paper provides a review of the barriers that are making sustainability unattractive for corporate organisations. Finance gaps, the complexity of organisational sustainability, reporting frameworks, tools, and procedures coupled with considerable marketing and communication in a business-as-usual environment are key barriers to corporate sustainability. Our findings provide recommendations for policymakers, and stakeholders across the corporate sustainability platform by delivering a holistic approach to overcome the bottlenecks for implementation, action, and monitoring.Unfunde
Shakespeare in the Park: The Taming of the Shrew
- Author
- Atkinson Ralph
- Barclay Andrew
- Bond Ruth
- Brodie Stephen
- Caceres Leticia
- Callaghan Michael
- Clark Samuel
- Cockburn Damien
- Dashwood Timothy
- Dowling Travis
- Faramand Shideh
- Foy Kate
- Gillard Jess
- Hurry Cameron
- Johnson Kirsty
- Knight Jennifer
- Lambley Kathryn
- Levien Hannah
- O'Rourke Shaun
- Parsons Shannon
- Poole Daniel
- Roberts Rebecca
- Smith Lorinda
- Smith Melanie
- Stapleton Ally
- Taylor-Smith Carole
- Trent Natalie
- Walsh Genevieve
- Wells Col
- Willems Chris
- Publication venue
- Publication date
- 01/02/2005
- Field of study
Get PDFRaman Spectroscopy Provides a Noninvasive Approach for Determining Biochemical Composition of the Pregnant Cervix In Vivo
- Author
- Anthony
- Badir
- Barr
- Baños
- Behrman
- Bergholt
- Blencowe
- Callaghan
- Catalano
- Chrit
- Committee on Practice Bulletins-Obstetrics
- Crow
- Duraipandian
- Feltovich
- Feltovich
- Goldenberg
- Grimbergen
- Haka
- Hamilton
- Havelock
- Hornung
- Huang
- Iams
- Iams
- Jess
- Jokhi
- Kamemoto
- Kanter
- Ko
- Krishna
- Lee
- Lyng
- Maul
- Maul
- McFarlin
- Moroz
- Morris
- Myers
- Myers
- Reusch
- Robinson
- Ruiz
- Schlembach
- Shetty
- Sigurdsson
- Society for Maternal-Fetal Medicine Publications Committee
- Sotiriadis
- Stone
- Swiatkowska-Freund
- Vargis
- Vargis
- Vargis
- Vargis
- Word
- Zhang
- Publication venue
- Hosted by Utah State University Libraries
- Publication date
- 01/07/2014
- Field of study
No full texthe molecular changes that occur with cervical remodelling during pregnancy are not completely understood. This study reviews Raman spectroscopy, an optical technique for detecting changes in the pregnant cervix, and reports preliminary studies on cervical remodelling in mice that suggest that the technique provides advantages over other methods. CONCLUSION: Raman spectroscopy is sensitive to biochemical changes in the pregnant cervix and has high potential as a tool for detecting premature cervical remodelling in pregnant women
High-density functional-RNA arrays as a versatile platform for studying RNA-based interactions
- Author
- Anastasia J Callaghan
- Andrew R Pickford
- Bardill
- Buenrostro
- Carthew
- Cech
- Charlotte A Henderson
- Cho
- Dersch
- Etzel
- Gao
- Gottesman
- Green
- Gruber
- Hall
- Hartmuth
- Helen A Vincent
- Holden
- Jack O Phillips
- Jess Healy
- Jiang
- Kurupati
- Lenz
- Louise E Butt
- Martin Devonshire
- Matsui
- McCown
- Nicolas Locker
- Ozer
- Pardee
- Pardee
- Pasquinelli
- Rasmussen
- Rupaimoole
- Seitz
- She
- Srisawat
- Storz
- Stuart J Conway
- Svensson
- Tome
- Udekwu
- Viegas
- Vincent
- Wahlestedt
- Wang
- Wu
- Zhu
- Zuker
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
No full textRaman spectroscopy provides a noninvasive approach for determining biochemical composition of the pregnant cervix in vivo
- Author
- Anthony
- Badir
- Barr
- Baños
- Behrman
- Bergholt
- Blencowe
- Callaghan
- Catalano
- Chrit
- Committee on Practice Bulletins-Obstetrics
- Crow
- Duraipandian
- Feltovich
- Feltovich
- Goldenberg
- Grimbergen
- Haka
- Hamilton
- Havelock
- Hornung
- Huang
- Iams
- Iams
- Jess
- Jokhi
- Kamemoto
- Kanter
- Ko
- Krishna
- Lee
- Lyng
- Maul
- Maul
- McFarlin
- Moroz
- Morris
- Myers
- Myers
- Reusch
- Robinson
- Ruiz
- Schlembach
- Shetty
- Sigurdsson
- Society for Maternal-Fetal Medicine Publications Committee
- Sotiriadis
- Stone
- Swiatkowska-Freund
- Vargis
- Vargis
- Vargis
- Vargis
- Word
- Zhang
- Publication venue
- 'Wiley'
- Publication date
- Field of study
No full textStratified analyses refine association between TLR7 rare variants and severe COVID-19
- Author
- A. Gulati
- Aaron Butler
- Aayesha Kazi
- Abdelhakim Altabaibeh
- Abdul Kayani
- Abhinav Gupta
- Abigail Crew
- Abigail Knighton
- Abigail Short
- Abigail Taylor
- Abiola Harrison
- Adam Brayne
- Adam Brown
- Adam Loveridge
- Adama Fofano
- Aditya Kuravi
- Adriana Botello
- Adriana Palom
- Agilan Kaliappan
- Agilan Kaliappan
- Agnieszka Kubisz-Pudelko
- Agustín Albillos
- Ahmed Zaki
- Ailbhe Brady
- Ailsa Golightly
- Ailstair Nichol
- Ainhi Mac
- Ajay Raithatha
- Alain Vuylsteke
- Alan Maclean
- Alan Morrison
- Alan Neal
- Alasdair Bamford
- Alasdair Hay
- Alastair McGregor
- Alastair Rose
- Alastair Thomas
- Aled Morgan
- Alessandra Bandera
- Alessio Gerussi
- Alex Howlett
- Alex Lyon
- Alex McCurdy
- Alex Puxty
- Alexander Hoischen
- Alexandra Metcalfe
- Alexandra Williams
- Alexandre C. Pereira
- Alfredo Serrano-Ruiz
- Alice Harvey
- Alice Michael Mitchell
- Alice Nicholson
- Alice Poole
- Alice Thomas
- Alicia A.C. Waite
- Alicia Knight
- Alicia Price
- Alison Brown
- Alison Brown
- Alison Durie
- Alison Ghosh
- Alison Harrison
- Alison Lewis
- Alison Lye
- Alison Quinn
- Alison Turnbull
- Alison Williams
- Alison Wilson
- Alissa Kent
- Alistair Gales
- Alistair Hughes
- Alistair Meikle
- Alistair Nichol
- Alistair Roy
- Allison Daniels
- Alun Rees
- Amanda Ayers
- Amanda Cowton
- Amanda Lyle
- Amanda McGregor
- Amanda Sanderson
- Amanda Tyler
- Amanda Whileman
- Amber Cox
- Amber Ford
- Ambreen Tariq
- Amelia Daniel
- Amelia Stacey
- Ami Wilkinson
- Amie Reddy
- Amit Patel
- Amitaa Maharajh
- Amro Katary
- Amy Bowes
- Amy Clark
- Amy Collins
- Amy Cunningham
- Amy Easthope
- Amy Easthope
- Amy Easthope
- Amy Gardner
- Amy Kirkby
- Amy Pickard
- Amy Shepherd
- Ana Alvaro
- Ana Lisboa
- Ana Luisa Tomas
- Ana Vochin
- Anca Gherman
- Andre Franke
- Andrea Biondi
- Andrea Kay
- Andrea Webster
- Andres Naranjo
- Andrew Burtenshaw
- Andrew Fagan
- Andrew Gratrix
- Andrew Higham
- Andrew Higham
- Andrew Stenhouse
- Andrew Swain
- Andy Campbell
- Andy Drummond
- Andy Law
- Anelise C. Zborowski
- Aneta Bociek
- Anezka Pratley
- Angela Allan
- Angela Andrew
- Angela Lombardi
- Angharad Williams
- Angie Fawkes
- Angiy Michael
- Anil Hormis
- Anila Sukumaran
- Anisha Sukha
- Anita Agasou
- Anita Furlong
- Anna Cavazza
- Anna Joseph
- Anna Morris
- Anna Reed
- Anna Reyes
- Anna Roynon-Reed
- Annalisa Dance
- Anne Carter
- Anne Cowley
- Anne Cowley
- Anne Emma Heron
- Anne Haldeos
- Anne Hayes
- Anne Hudson
- Anne Nicholson
- Anne Nicholson
- Anne Saunderson
- Anne Todd
- Anne Zak
- Annette Hilldrith
- Annette Nilsson
- Anthony Barron
- Anthony Gordon
- Anthony Murphy
- Anthony Ng
- Anthony Rostron
- Anton Mayer
- Antonio Julià
- Aparna George
- Archana Bashyal
- Arianna Bellini
- Arianna Tucci
- Armorel Salberg
- Arnold Dela Rosa
- Arunkumar Ganesan
- Ascanio Tridente
- Ashar Ahmed
- Ashley Kinch
- Ashok Sundar
- Asifa Ali
- Atideb Mitra
- Atul Garg
- Audrey Coutts
- Austin Rattray
- Avril Donaldson
- Axel Schmidt
- Ayaa Eltayeb
- Ayesha Javaid
- Azmerelda Abraheem
- Baird Tracy
- Bally Purewal
- Balvinder Baines
- Barbara Winter-Goodwin
- Barney Scholefield
- Barry Milligan
- Beatriz Nafria
- Becky Lenagh
- Beena David
- Beena Eapen
- Belinda Roberts
- Ben Attwood
- Ben Creagh-Brown
- Ben Donne
- Ben Player
- Benedict Andrew
- Benjamin Shelley
- Benjamin Thomas
- Berina Zametica
- Bernadette Gallagher
- Bernadette King
- Bernard Hadebe
- Bethan Blackledge
- Bethan Blackledge
- Bethan Charles
- Bethan Deacon
- Bethan Deacon
- Bethan Gay
- Bethan Ogg
- Bethan Stowe
- Bethany Gumbrill
- Beverley Faulkner
- Beverley Wadams
- Bijal Patel
- Bijoy Mathew
- Borislava Borislavova
- Brendan Sloan
- Brian Digby
- Brian Johnston
- Brian Wilkinson
- Brice Djeugam
- Bridget Fuller
- Bridget Hopkins
- Bridgett Masunda
- Brigid Hairsine
- Brijesh Patel
- Britt-Sabina Löscher
- Bryan Yates
- Callum Kaye
- Callum Mackay
- Camilla Ledgard
- Carey Tierney
- Carina Cruz
- Carl Murphy
- Carla Pothecary
- Carla Pothecary
- Carlos Castro Delgado
- Carly Price
- Carmel Stuart
- Carole Hays
- Caroline Abernathy
- Caroline Burnett
- Caroline Davis
- Caroline Wrey Brown
- Carrie Demetriou
- Carter David
- Caspar I. van der Made
- Catherine Borra
- Catherine Dennis
- Catherine Dexter
- Catherine Jardine
- Catherine Novis
- Cathrine Basikolo
- Cathy Jones
- Cecilia Ahmed
- Cecilia Peters
- Ceilia Boz
- Celia Harris
- Ceri Battle
- Ceri Lynch
- Champa Jetha
- Chantal McParland
- Charlene Davies
- Charles Hinds
- Charles Piercy
- Charlie Dunmore
- Charlie Vigurs
- Charlotte Coates
- Charlotte Downes
- Charlotte Eckbad
- Charlotte Humphrey
- Charlotte Kamundi
- Charlotte Summers
- Charlotte Summers
- Charlotte Willis
- Charmaine Shovelton
- Chenqing Zheng
- Cheryl Finch
- Cheryl Graham
- Cheryl Marriott
- Chetan Parmar
- Chloe Davison
- Chloe Lyons
- Chloe Rishton
- Chris Marsh
- Chris P. Ponting
- Chris Thorpe
- Christine Almaden-Boyle
- Christine Eastgate-Jackson
- Christine Sicat
- Christopher Fine
- Christopher McParland
- Christopher Thompson
- Christopher Wasson
- Christopher Whitton
- Chrsitopher Woodford
- Chunda Sri-Chandana
- Ciara Collins
- Claire Cheyne
- Claire Fox
- Claire Gorman
- Claire Hewitt
- Claire Jarman
- Claire Jennings
- Claire Marie Beith
- Claire Nolan
- Claire Phillips
- Claire Phillips
- Claire Prendergast
- Clare Bradley
- Clare Buckley
- Clare Finney
- Clare Smedley
- Clare Tibke
- Clare Whyte
- Colene Adams
- Colin Begg
- Colin Begg
- Colin Wells
- Corinne Pawley
- Corrienne McCulloch
- Craig Brandwood
- Craig Brantwood
- Craig Denmade
- Craig Sell
- Cristiana Bianco
- Dabheoc Coleman
- Dan Hawcutt
- Dana Raynard
- Daniel Horner
- Daniel Martin
- Daniel Menzies
- Daniele Cristiano
- Daniele Prati
- Danielle Childs
- Danielle McLaughlan
- Danielle Thornton
- Danielle Walker
- Danny McAuley
- Daphene Clarke
- Dario Salutous
- Dariusz Tetla
- Darsh Potla
- Dave Hope
- Dave Vedage
- David Antcliffe
- David Baptista
- David Brealey
- David Brealey
- David Collier
- David Ellinghaus
- David Foote
- David Golden
- David Helm
- David Loader
- David Maslove
- David O. Hamilton
- David Pogson
- David Shaw
- David Tyl
- David Wright
- Dawn Collier
- Dawn Hales
- Dawn Jones
- Dawn Law
- Dawn Trodd
- Deanna Stephens
- Debbie Branney
- Debbie Hamilton
- Deborah Afolabi
- Deborah Baines
- Deborah Butcher
- Deborah Dawson
- Deborah Melia
- Deborah Smyth
- Deborah Warren
- Deborah White
- Dee Mullan
- Dee Mullan
- Deepak Subramanian
- Deirdre Fottrell-Gould
- Delordson Kallon
- Denise Cosgrove
- Denise Donaldson
- Denise Griffin
- Denise McFarland
- Denise O'Connor
- Denise Skinner
- Denise Skinner
- Denise Webster
- Dewi Williams
- Dhanalakshmi Bakthavatsalam
- Dhaneesha Senaratne
- Dharam Purohit
- Di Wood
- Diane Kelly
- Diane Lomas
- Dina Bell
- Dominic Strachan
- Donna Duffin
- Dorota Banach
- Dorota Burda
- Dorota Potoczna
- Dr Ben Chandler
- Drew Goodchild
- Duncan Kaye
- Eamon Coughlan
- Eamon Raith
- Eamon Raith
- Edna Fernandes Da Gloria
- Edward Combes
- Edward Jude
- Ekaterina Watson
- Ekta Merwaha
- Elaine Brinkworth
- Elaine Heeney
- Elaine Stephenson
- Eleanor Andrews
- Eleanor Corcoran
- Eleanor Moncur
- Eleanor Smith
- Elena Anastasescu
- Elena Apetri
- Elena Maccacari
- Elizabeth Allan
- Elizabeth Goff
- Elizabeth Gordon
- Elizabeth Horsley
- Elizabeth Radford
- Elizabeth Smithson
- Elizabeth Stones
- Elizabeth Timlick
- Elizabeth Wilby
- Ellen Brown
- Ellen Jerome
- Ellen Knights
- Ellie Davies
- Ellie Mcmaster
- Elvezia M. Paraboschi
- Emily Beech
- Emily Bevan
- Emily Johnson
- Emily London
- Emily Peasgood
- Emily Peasgood
- Emma Carter
- Emma Collins
- Emma Dobson
- Emma Dooks
- Emma Fisher
- Emma Gendall
- Emma Goodwin
- Emma Lee
- Emma Low
- Emma McKenna
- Emma Meadows
- Emma Perkins
- Emma Stoddard
- Emma Tagliavini
- Emma Thomas
- Emma Tilney
- Emma Virgilio
- Emma Williams
- Eoghan Meaney
- Erika Salciute
- Eriko Morino
- Erin Collins
- Erin Trumper
- Erola Pairo-Castineira
- Estefania Treus Gude
- Esther Daubney
- Esther Duncan
- Esther Mwaura
- Ethel Black
- Euan Murdoch
- Eva Beranova
- Evie Headlam
- Evita Pappa
- Faith Kibutu
- Farah Nasir
- Fatima Bibi
- Faye Moore
- Felicity Anderson
- Felicity Williams
- Ffyon Davies
- Filip Taneski
- Fiona Auld
- Fiona Barrett
- Fiona Farquhar
- Fiona Griffiths
- Fiona Kelly
- Fiona McNeela
- Fiona Trim
- Fiona Wakinshaw
- Flora Peyvandi
- Fran Hurford
- Francesco Blasi
- Francesco Malvestiti
- Frater Alasdair
- Gabor Debreceni
- Gabriella Lindergard
- Gamu Lubimbi
- Gareth A.L. Jones
- Gareth Hughes
- Gareth Kennard-Holden
- Gary H. Mills
- Gary Semple
- Gayathri Subramanian
- Gayatri Ramakrishnan
- Gemma Castaño-Vinyals
- Gemma Millen
- Gemma Williams
- Gemma Wray
- Geoff Watson
- George Franke
- George Tsinaslanidis
- Georgia Bercades
- Georgia Durrant
- Georgia Efford
- Georgina Randell
- Geraldine Hambrook
- Geraldine Sloane
- Geraldine Ward
- Giacomo Grasselli
- Gill Arbane
- Gillian Andrew
- Gillian Bell
- Gillian Hobden
- Giuseppe Citerio
- Giuseppe Foti
- Gladys Martir
- Glykeria Pakou
- Gordan McCreath
- Gordon Houston
- Grace Padden
- Grainne O'Connor
- Gwenllian Sera Howe
- Gwyneth Davies
- Hafiz Rehman
- Hamza Meghari
- Hannah Ellis
- Hannah Golding
- Hannah Sainsbury
- Hannah Williams
- Hannah-Louise Wood
- Hanning Mal
- Harini Rangarajan
- Harish Venkatesh
- Harriet Kent
- Harriet Noble
- Harriet Pearson
- Hayley Bates
- Hayley Blakemore
- Hayley Middleton
- Heather Biggs
- Heather Button
- Heather Fox
- Heather McGuinness
- Heather Passmore
- Heather Savill
- Heather Weston
- Heather Willis
- Helder Filipe
- Helen Blackman
- Helen Campbell
- Helen Hanson
- Helen Hill
- Helen Holcombe
- Helen Jeffrey
- Helen Langton
- Helen Millward
- Helen Newell
- Helen Quinn
- Helen Szoor-McElhinney
- Helen T-Michael
- Helen Tench
- Helen Thomas
- Helen Tivenan
- Helen Tranter
- Helen Trower
- Helen Wassall
- Helen Whittle
- Helen Wild
- Helena Hanratty
- Helena Prady
- Henrik Reschreiter
- Henry Houlden
- Hollie Bancroft
- Hollie Brooke
- Hollie Curgenven
- Holly Belfield
- Holly Coles
- Hugh Montgomery
- Ian Clement
- Ian Edmond
- Ian Turner-Bone
- Ian White
- Igor Otahal
- Igor Otahal
- Ilaria Beretta
- Imrun Nagra
- India McKenley
- Indra Chadbourn
- Inez Wynter
- Ingeborg D. Welters
- Ingrid Hass
- Inthakab Ali Mohamed Ali
- Iona Burn
- Irene Macharia
- Irene Pinzuti
- Irving Mayangao
- Isheunesu Mapfunde
- Isobel Birkinshaw
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- Muhammad Hijazi
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- Sabi Gurung Rai
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- Sara-Beth Sutherland
- Sarah Bean
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- Shona C. Moore
- Shondipon Laha
- Shruti Agrawal
- Shuying Wei
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- Sinduya Srikaran
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- Sinead Kelly
- Siobhain Carmody
- Sivarupan Selvanayagam
- Sohphie Birch
- Sonia Sathe
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- Sophie Arnold
- Sophie Kennedy-Hay
- Sophie Murdoch
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- Sophie Twiss
- Sorrell Tilbey
- Soumendu Manna
- Srikanth Chukkambotla
- Srinivas Jakkula
- Stacey Duffy
- Stavros Fotiadis
- Stella Metherell
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- Sue Spencer
- Sukamal Das
- Suleman Mulla
- Sumit Kumar
- Sundeep Kaul
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- Susan Fowler
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- Susan O'Connell
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- Susannah Glasgow
- Susannah Leaver
- Susanne Cathcart
- Susie Ferguson
- Susie O'Sullivan
- Suzanne Allibone
- Suzanne Brooks
- Suzanne Campbell
- Suzanne Clements
- Suzanne Wood
- Suzie Marriott
- Sweyn Garrioch
- Syamlan Ali
- Tabitha Newman
- Tabitha Rees
- Tahera Patel
- Tahira Ishaq
- Tamas Szakmany
- Tammy Gilchrist
- Tara McHugh
- Tatiana Pogreban
- Taya Anderson
- Teishel Joefield
- Teresa Behan
- Teresa Scott
- Terry Martin
- Thogulava Kannan
- Thomas Bemand
- Thomas Kong
- Thomas Lamb
- Tim Geary
- Tim Martindale
- Tim Owen Jones
- Tim Smith
- Tim Smith
- Timothy Felton
- Timothy Walsh
- Tina Coventry
- Tinashe Samakomva
- Tobias Rankin
- Tom Lawton
- Tonicha Nortcliffe
- Tony Wackett
- Toran Williams
- Tracey Cosier
- Tracey Hodgkiss
- Tracie Arden
- Tracy Duncan
- Tracy Hazelton
- Tracy Lewis
- Tracy Marsden
- Tracy Wood
- Trevor Paterson
- Una Poultney
- Val Irvine
- Valeria Rimoldi
- Valerie Beech
- Valerie Joan Page
- Valli Ratnam
- Vanessa Linnett
- Vanessa Rivers
- Varun Sarathy
- Veronica Wagstaff
- Veronika Pristopan
- Vicky Martinson
- Vicky Thomas
- Vicky Thwaites
- Vicky Thwaites
- Victoria Bastion
- Victoria Bridgett
- Victoria Clark
- Victoria Frost
- Victoria Lake
- Victoria Maynard
- Victoria Maynard
- Victoria Parris
- Victoria Parris
- Victoria Slater
- Victoria Tuckey
- Victoria Turner
- Victoria Waugh
- Vidya Kasipandian
- Vikki Crickmore
- Vikram Anumakonda
- Vinodh Krishnamurthy
- Vinodh Krishnamurthy
- Vishal Amin
- Wall Alanna
- Waqas Khaliq
- Waqas Khaliq
- Watkins Claire
- Wendy Goddard
- Wendy Harrison
- Wendy McCormick
- West Joe
- Wiesia Woodyatt
- Wild Laura
- William James Hurt
- Wilna Oosthuyzen
- Xavier Farré
- Xinyi Qiu
- Yasmin Choudhury
- Yasmin Death
- Yasmin Hussain
- Yolanda Baird
- Yusuf Cheema
- Yvette Thirlwall
- Yvonne Jackson
- Zahira Maqsood
- Zakaula Belagodu
- Zena Bradshaw
- Ziortza Fernandez
- Zoe Alldis
- Zoe Coton
- Zoe Daly
- Zoe Garland
- Zoe Lamond
- Zoe Prime
- Zoe Scott
- Zohra Omar
- Zohreh Farzad
- Publication venue
- Elsevier
- Publication date
- 01/10/2024
- Field of study
No full textSummary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (<60 years) cases with no reported clinical risk factors (n = 378), compared to 0.24% of controls (odds ratio [OR] = 12.3, p = 1.27 × 10−10). Incorporation of the results of either functional assays or protein modeling led to a pronounced increase in effect size (ORmax = 46.5, p = 1.74 × 10−15). Association signals for the X-chromosomal gene TLR7 were also detected in the female-only subgroup, suggesting the existence of additional mechanisms beyond X-linked recessive inheritance in males. Additionally, supporting evidence was generated for a contribution to severe COVID-19 of the previously implicated genes IFNAR2, IFIH1, and TBK1. Our results refine the genetic contribution of rare TLR7 variants to severe COVID-19 and strengthen evidence for the etiological relevance of genes in the interferon signaling pathway
