40 research outputs found
Strengthening Unarmed Community Self-protection in Cameroon's Anglophone Conflict
Get PDFThis brief discusses the innovative unarmed civilian self-protection strategies employed by individuals, groups and communities affected by the armed conflict and their accompanying challenges. In doing so, it not only emphasises the urgency in finding sustainable solution to the conflict, but equally demonstrates the resilience, resourcefulness, and pro-activeness of civilians in protecting themselves in violent contexts. Some key recommendations are provided for future policy and programmatic interventions
From ‘Anglophone Problem’ to ‘Anglophone Conflict’ in Cameroon:Assessing Prospects for Peace
Get PDFSince 2017, an armed conflict has been raging in the English-speaking regions of Cameroon between separatist forces and the Cameroonian military. This review analyses the historical origins and root causes of the conflict; the trigger mechanism of rising protests and state repression in 2016; the emergence and evolution of the armed conflict over the past 5 years; its impact on civilians; and hopes for peace. However, there is currently little prospect for conflict resolution as the Cameroon government appears intent on ignoring limited international pressure, maintaining the charade that the "security crisis" is over and reconstruction is underway, while continuing its counter-insurgency strategy to militarily defeat the armed separatist groups. We note that, while the desire for peace is profound, the political status quo is no longer tolerable nor acceptable, with conflict resolution dependent on political changes that provide, at a minimum, the Anglophone regions with greater autonomy and protection of their particular identity and institutions.Seit dem Jahr 2017 gibt es in den englischsprachigen Regionen Kameruns einen bewaffneten Konflikt zwischen Separatisten und der Regierungsarmee. In diesem Artikel werden die historischen Ursprünge und Ursachen des Konfliktes aufgezeigt, die Auslöser der zunehmenden Proteste und der staatlichen Repression im Jahr 2016, die Entstehung und Entwicklung des Konfliktes über fünf Jahre, seine Auswirkungen auf die Zivilbevölkerung und die Hoffnungen auf Frieden. Die Aussichten auf eine Konfliktlösung sind gering, da die kamerunische Regierung offenbar gewillt ist, den begrenzten internationalen Druck zu ignorieren und die Scharade aufrechtzuerhalten, dass die "Sicherheitskrise" vorbei und der Wiederaufbau im Gange sei, während sie gleichzeitig ihre Strategie der Aufstandsbekämpfung fortsetzt, um die bewaffneten separatistischen Gruppen militärisch zu besiegen. Wir stellen fest, dass der Wunsch nach Frieden zwar groß, der politische Status quo jedoch nicht länger tolerierbar oder akzeptabel ist. Die Lösung des Konflikts hängt von politischen Veränderungen ab, die den anglophonen Regionen zumindest eine größere Autonomie und den Schutz ihrer Identität und Institutionen ermöglichen
Shrinking Civic Space and the Role of Civil Society in Resolution of Conflict in Anglophone Cameroon
Get PDFH-chromatic symmetric functions
Full text linkWe introduce -chromatic symmetric functions, , which use the
-coloring of a graph to define a generalization of Stanley's chromatic
symmetric functions. We say two graphs and are -chromatically
equivalent if , and use this idea to study
uniqueness results for -chromatic symmetric functions, with a particular
emphasis on the case is a complete bipartite graph. We also show that
several of the classical bases of the space of symmetric functions, i.e. the
monomial symmetric functions, power sum symmetric functions, and elementary
symmetric functions, can be realized as -chromatic symmetric functions. We
end with some conjectures and open problems.Comment: 38 pages; corrected typos and clarified some detail
Exploring Unarmed Civilian Self-Protection in Cameroon’s Anglophone Conflict
Get PDFThis study explores the unarmed civilian self-protection measures taken by individuals and communities who live in the midst of ongoing armed conflict in Cameroon’s two Englishspeaking regions, the North West and South West
South American Plasmodium falciparum after the Malaria Eradication Era: Clonal Population Expansion and Survival of the Fittest Hybrids
Get PDFMalaria has reemerged in many regions where once it was nearly eliminated. Yet the source of these parasites, the process of repopulation, their population structure, and dynamics are ill defined. Peru was one of malaria eradication's successes, where Plasmodium falciparum was nearly eliminated for two decades. It reemerged in the 1990s. In the new era of malaria elimination, Peruvian P. falciparum is a model of malaria reinvasion. We investigated its population structure and drug resistance profiles. We hypothesized that only populations adapted to local ecological niches could expand and repopulate and originated as vestigial populations or recent introductions. We investigated the genetic structure (using microsatellites) and drug resistant genotypes of 220 parasites collected from patients immediately after peak epidemic expansion (1999–2000) from seven sites across the country. The majority of parasites could be grouped into five clonal lineages by networks and AMOVA. The distribution of clonal lineages and their drug sensitivity profiles suggested geographic structure. In 2001, artesunate combination therapy was introduced in Peru. We tested 62 parasites collected in 2006–2007 for changes in genetic structure. Clonal lineages had recombined under selection for the fittest parasites. Our findings illustrate that local adaptations in the post-eradication era have contributed to clonal lineage expansion. Within the shifting confluence of drug policy and malaria incidence, populations continue to evolve through genetic outcrossing influenced by antimalarial selection pressure. Understanding the population substructure of P. falciparum has implications for vaccine, drug, and epidemiologic studies, including monitoring malaria during and after the elimination phase
Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon
Full text linkSoundscapes: Toward a Sounded Anthropology
Full text linkA generation of scholars in multiple disciplines has investigated sound in ways that are productive for anthropologists. We introduce the concept of soundscape as a modality for integrating this work into an anthropological approach. We trace its history as a response to the technological mediations and listening practices emergent in modernity and note its absence in the anthropological literature. We then trace the history of technology that gave rise to anthropological recording practices, film sound techniques, and experimental sound art, noting productive interweavings of these threads. After considering ethnographies that explore relationships between sound, personhood, aesthetics, history, and ideology, we question sound's supposed ephemerality as a reason for the discipline's inattention. We conclude with a call for an anthropology that more seriously engages with its own history as a sounded discipline and moves forward in ways that incorporate the social and cultural sounded world more fully. Copyright © 2010 by Annual Reviews. All rights reserved
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
Get PDFBackground
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
Get PDFBackground
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
